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1. (WO2018222880) MECHANO-ACTIVATED CONTROL OF GENE EXPRESSION

Pub. No.:    WO/2018/222880    International Application No.:    PCT/US2018/035407
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: A61K 35/17
A61K 48/00
A61P 35/00
C07K 14/705
C07K 19/00
C12N 5/0783
Applicants: TRUSTEES OF BOSTON UNIVERSITY
Inventors: NGO, John T.
Title: MECHANO-ACTIVATED CONTROL OF GENE EXPRESSION
Abstract:
Described herein are compositions, methods, and systems for modulating Notch receptor activation. Aspects of the invention relate to synthetic proteins comprising at least a Notch NRR (Negative Regulatory Region)-binding scFV fused to a transmembrane domain. Another aspect of the invention relates to a drug-dependent synthetic protein. Engineered cells comprising the synthetic protein are additionally described herein.