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1. (WO2018222856) PHOTONIC INACTIVATION OF PATHOGENS

Pub. No.:    WO/2018/222856    International Application No.:    PCT/US2018/035369
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: A23L 3/26
A61M 1/36
A61L 2/00
A61L 2/08
C02F 1/30
Applicants: EMD MILLIPORE CORPORATION
TRUSTEES OF BOSTON UNIVERSITY
Inventors: ASHER, Damon, R.
ERRAMILLI, Shyamsunder
GAGNE, George
GILLESPIE, Christopher
GUMMULURU, Suryaram
HONG, Mi, Kyung
MIURA, Ayako
NAZARI, Mina, N.
REINHARD, Bjoern
SOUZA, Kathleen
XI, Min
Title: PHOTONIC INACTIVATION OF PATHOGENS
Abstract:
Devices, systems and methods for the inactivation of pathogens such as viruses in a liquid medium containing products such as pharmaceutical compounds are presented. These are useful, for example, for the inactivation of viruses in liquids containing antibody pharmaceuticals, and make use of one or more of flow-through inactivation, plasmonic virus inactivation enhancement, mode matching between hydrodynamic flow profile and laser intensity profile, and nonlinear flow geometries. The methods allow flow-through pathogen inactivation while avoiding collateral damage to products to be decontaminated.