Search International and National Patent Collections

1. (WO2018222854) HUMAN ANTIBODIES TO BET V 1 AND METHODS OF USE THEREOF

Pub. No.:    WO/2018/222854    International Application No.:    PCT/US2018/035366
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri Jun 01 01:59:59 CEST 2018
IPC: C07K 16/16
A61K 39/00
Applicants: REGENERON PHARMACEUTICALS, INC.
Inventors: ORENGO, Jamie M.
MURPHY, Andrew J.
BADITHE, Ashok T.
KAMAT, Vishal
LIU, Yashu
Title: HUMAN ANTIBODIES TO BET V 1 AND METHODS OF USE THEREOF
Abstract:
Provided herein are antibodies that bind Fagales allergens, Fagales related allergens, birch pollen, or Bet v 1, compositions comprising the antibodies, nucleic acids encoding the antibodies, and methods of using the antibodies. According to certain embodiments, the antibodies are fully human monoclonal antibodies that bind to Bet v 1. The antibodies are useful for binding Bet v 1 in vivo, thus preventing binding of the allergen to pre-formed IgE on the surface of mast cells or basophils. In doing so, the antibodies act to prevent the release of histamine and other inflammatory mediators from mast cells and/or basophils, thus ameliorating the untoward response to the Fagales allergens in sensitized individuals.