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1. (WO2018222850) RECOMBINANT ROBO2 PROTEINS, COMPOSITIONS, METHODS AND USES THEREOF
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Pub. No.: WO/2018/222850 International Application No.: PCT/US2018/035361
Publication Date: 06.12.2018 International Filing Date: 31.05.2018
IPC:
C07K 14/705 (2006.01) ,A61K 38/17 (2006.01) ,C12N 15/62 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
705
Receptors; Cell surface antigens; Cell surface determinants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
62
DNA sequences coding for fusion proteins
Applicants:
PFIZER INC. [US/US]; 235 East 42nd Street New York, NY 10017, US
BOSTON MEDICAL CENTER CORPORATION [US/US]; One Boston Medical Center Place Boston, MA 02218, US
Inventors:
BERASI, Stephen; US
BUHLMANN, Janet, Elizabeth; US
HIGGINSON-SCOTT, Nathan; US
SHAMASHKIN, Michael; US
RUSSO, Matthew; US
GULLA, Stefano, V.; US
JUO, Zong, Sean; US
KODANGATTIL, Streekumar, R.; US
LU, Weining; US
FAN, Xueping; US
SALANT, David, J.; US
Agent:
HALEY, James, F., Jr.; US
Priority Data:
62/514,24202.06.2017US
62/663,08226.04.2018US
Title (EN) RECOMBINANT ROBO2 PROTEINS, COMPOSITIONS, METHODS AND USES THEREOF
(FR) PROTÉINES ROBO2 RECOMBINANTES, COMPOSITIONS, PROCÉDÉS ET UTILISATIONS ASSOCIÉS
Abstract:
(EN) The invention provides recombinant Roundabout Receptor 2 (ROBO2) proteins designed to bind SLIT ligands and prevent their binding to ROBO2 cell surface receptors. Also provided are methods for use of these recombinant ROBO2 proteins.
(FR) L'invention concerne des protéines recombinantes du récepteur 2 de la famille Roundabout (ROBO2) conçues pour se lier à des ligands SLIT et d'empêcher leur liaison à des récepteurs de surface cellulaire ROBO2. L'invention concerne également des procédés d'utilisation de ces protéines recombinantes ROBO2.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)