Some content of this application is unavailable at the moment.
If this situation persist, please contact us atFeedback&Contact
1. (WO2018222840) POLY(AMINE-CO-DISULFIDE ESTER) NANOPARTICLES AND METHODS OF USE
Latest bibliographic data on file with the International Bureau    Submit observation

Pub. No.: WO/2018/222840 International Application No.: PCT/US2018/035348
Publication Date: 06.12.2018 International Filing Date: 31.05.2018
IPC:
C08G 63/60 (2006.01) ,C08G 63/66 (2006.01) ,C08G 63/685 (2006.01) ,C08G 63/688 (2006.01) ,A61K 47/69 (2017.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63
Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
02
Polyesters derived from hydroxy carboxylic acids or from polycarboxylic acids and polyhydroxy compounds
60
derived from the reaction of a mixture of hydroxy carboxylic acids, polycarboxylic acids and polyhydroxy compounds
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63
Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
66
Polyesters containing oxygen in the form of ether groups
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63
Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
68
Polyesters containing atoms other than carbon, hydrogen, and oxygen
685
containing nitrogen
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
G
MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS
63
Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
68
Polyesters containing atoms other than carbon, hydrogen, and oxygen
688
containing sulfur
[IPC code unknown for A61K 47/69]
Applicants:
YALE UNIVERSITY [US/US]; Two Whitney Avenue New Haven, CT 06510, US
Inventors:
JIANG, Zhaozhong; US
LIU, Jie; CN
Agent:
PABST, Patrea, L.; US
Priority Data:
62/513,73701.06.2017US
62/585,91514.11.2017US
Title (EN) POLY(AMINE-CO-DISULFIDE ESTER) NANOPARTICLES AND METHODS OF USE
(FR) NANOPARTICULES DE POLY(AMINE-CO-ESTER DISULFURE) ET MÉTHODES D'UTILISATION
Abstract:
(EN) Polymers, containing one or more poly(amine-co-disulfide ester) polymeric units, and polymeric nanoparticles formed therefrom, are provided. The nanoparticles possess dual pH-responsive and redox- responsive properties, giving rise to enhanced release of cargo in disease- relevant microenvironments. The nanoparticles also show selective uptake by diseased tissues, compared to healthy tissues. The polymers are synthesized via enzyme-catalyzed polymerization reactions. Also provided are pharmaceutical compositions including nanoparticles having an effective amount of chemotherapeutic agents for inhibit the growth of tumor tissue.
(FR) L'invention concerne des polymères contenant un ou plusieurs motifs polymères poly(amine-co-ester disulfure), et des nanoparticules polymères formées à partir de ces derniers. Les nanoparticules présentent des propriétés simultanées de sensibilité au pH et aux conditions rédox, en occasionnant une libération renforcée de la protéine cargo dans les micro-environnements liés à une maladie. Les nanoparticules présentent également une absorption sélective par les tissus lésés, par comparaison avec des tissus sains. Les polymères sont synthétisés par des réactions de polymérisation catalysées par des enzymes. L'invention concerne également des compositions pharmaceutiques comprenant des nanoparticules contenant une quantité efficace d'agents chimiothérapeutiques, pour inhiber la croissance d'un tissu tumoral.
front page image
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)