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1. (WO2018222830) IDENTIFICATION OF EPIGENETIC SIGNATURES INDICATING CEREBRAL PALSY
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Pub. No.: WO/2018/222830 International Application No.: PCT/US2018/035335
Publication Date: 06.12.2018 International Filing Date: 31.05.2018
IPC:
C12Q 1/68 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
GENOME PROFILING, LLC [US/US]; Helen F. Graham Cancer Center & Research Institute 4701 Ogletown-Stanton Road, Suite 4300 Newark, Delaware 19713, US
THE NEMOURS FOUNDATION [US/US]; 4600 Touchton Road Bldg. 200, Suite 500 Jacksonville, Florida 32246, US
Inventors:
MARSH, Adam G.; US
AKINS, Jr., Robert E.; US
CROWGEY, Erin L.; US
ROBINSON, Karyn G.; US
Agent:
DOYLE, Kathryn; US
ARNOLD, Gianna Julian; US
CROTTY, Justin W.; US
EDDE, Chantal; US
KUO, Joseph; US
LANDRY, Brian R.; US
LAURO, Peter C.; US
MANAS, Michael G.; US
PLEHN-DUJOWICH, Debora; US
SILVA, Domingos J.; US
SIMPSON, Mark D.; US
TRUJILLO, Doreen Yatko; US
YOUNG, Jacque C.; US
Priority Data:
62/603,48601.06.2017US
Title (EN) IDENTIFICATION OF EPIGENETIC SIGNATURES INDICATING CEREBRAL PALSY
(FR) IDENTIFICATION DE SIGNATURES ÉPIGÉNÉTIQUES INDIQUANT UNE PARALYSIE CÉRÉBRALE
Abstract:
(EN) In one aspect, the invention provides a method of detecting cerebral palsy in a subject. The method includes: determining a methylation state for each of a plurality of cytosine-guanine dinucleotide (CpG) sites in a sample obtained from the subject, calculating a differential methylation level based on the methylation states of the plurality of CpG sites, and comparing the differential methylation level to a predetermined reference level. When the differential methylation level deviates from the predetermined reference level, the presence of cerebral palsy is indicated in the patient.
(FR) Selon un aspect, l'invention concerne un procédé de détection de paralysie cérébrale chez un sujet. Le procédé comprend les étapes consistant à : déterminer un état de méthylation pour chaque site d'une pluralité de sites de dinucléotide cytosine-guanine (CpG) dans un échantillon obtenu à partir du sujet, calculer un niveau de méthylation différentiel sur la base des états de méthylation de la pluralité de sites CpG, et comparer le niveau de méthylation différentiel avec un niveau de référence prédéfini. Lorsque le niveau de méthylation différentiel s'écarte du niveau de référence prédéfini, la présence d'une paralysie cérébrale est indiquée dans le patient.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)