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1. (WO2018222795) SUBSTITUTED NITROGEN CONTAINING COMPOUNDS
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Pub. No.: WO/2018/222795 International Application No.: PCT/US2018/035270
Publication Date: 06.12.2018 International Filing Date: 31.05.2018
IPC:
C07D 405/14 (2006.01) ,C07D 413/14 (2006.01) ,C07D 417/14 (2006.01) ,C07D 487/04 (2006.01) ,A61P 9/00 (2006.01) ,A61K 31/5355 (2006.01) ,A61K 31/53 (2006.01) ,A61K 31/495 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
405
Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
413
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
417
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/196
14
containing three or more hetero rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
535
having six-membered rings with at least one nitrogen and at least one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
5355
Non-condensed oxazines containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
53
having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
Applicants:
BRISTOL-MYERS SQUIBB COMPANY [US/US]; Route 206 and Province Line Road Princeton, New Jersey 08543, US
Inventors:
YADAV, Navnath Dnyanoba; IN
BHIDE, Rajeev S.; US
BORA, Rajesh Onkardas; IN
GUNAGA, Prashantha; IN
PANDA, Manoranjan; IN
PRIESTLEY, Eldon Scott; US
RICHTER, Jeremy; US
Agent:
VANATTEN, Mary; US
CLAUSS, Isabelle M.; US
DELAUNEY, Ashton J.; US
FARQUHARSON TORRES, Serena; US
GOLIAN, Paul D.; US
GREENBLATT, Gary D.; US
GUO, Z. Angela; US
HADAD, Henry; US
HAN, Bo; US
JACOBSEN, Barry; US
KORSEN, Elliott; US
LIU, Hong; US
LU, Yong; US
PARLET, Nickki L.; US
WALSH, Brian J.; US
EPPERSON, James; US
MINGO, Pamela A.; US
BELLOMY, Gregory R.; US
CHAO, Yuan; US
COULTER, Kathryn; US
HAI, Bing; US
Priority Data:
20171101929301.06.2017IN
20181100448606.02.2018IN
Title (EN) SUBSTITUTED NITROGEN CONTAINING COMPOUNDS
(FR) COMPOSÉS CONTENANT DE L'AZOTE SUBSTITUÉ
Abstract:
(EN) Disclosed are compounds of Formula (I): or a salt thereof, Formula (II) wherein R1 is: or; each W is independently NR1b or O; Z is a bond or CHR1d; and R1, R2, Rd, R3a, R3b, L1, B, V, Y, and n are defined herein. Also disclosed are methods of using such compounds as inhibitors of ROMK, and pharmaceutical compositions comprising such compounds. These compounds are useful in treating cardiovascular diseases.
(FR) La présente invention concerne des composés de formule (I) : ou un sel de ceux-ci, formule (II) dans laquelle, R1 est : ou ; chaque W est indépendamment NR1b ou O ; Z représente une liaison ou CHR1d ; et R1, R2, Rd, R3a, R3b, L1, B, V, Y et n sont définis dans la description. L’invention concerne également des procédés d’utilisation de tels composés en tant qu’inhibiteurs du ROMK, et des compositions pharmaceutiques comprenant de tels composés. Ces composés sont utiles dans le traitement de maladies cardiovasculaires.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)