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1. (WO2018222773) FLUOROGENIC PEPTIDE SUBSTRATES FOR IN SOLUTION AND SOLID PHASE FACTOR XA MEASUREMENTS

Pub. No.:    WO/2018/222773    International Application No.:    PCT/US2018/035215
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: C12Q 1/37
C07K 1/04
Applicants: CHAN, Eugene, Y.
Inventors: CHAN, Eugene, Y.
Title: FLUOROGENIC PEPTIDE SUBSTRATES FOR IN SOLUTION AND SOLID PHASE FACTOR XA MEASUREMENTS
Abstract:
The measurement of Factor Xa (FXa) enzymatic activity using novel fluorogenic peptide substrates that have a C-terminus cleavable fluorophore and optionally the ability to attach to a solid support. Fluorogenic measurements increase sensitivity and flexibility of measurements of enzymatic reactions over traditional absorbance-based approaches. The measurement of FXa generation is applicable to a range of biological reactions.