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1. (WO2018222765) SINGLE-STEP ATPS ENHANCED LFA DIAGNOSTIC DESIGN
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Pub. No.: WO/2018/222765 International Application No.: PCT/US2018/035204
Publication Date: 06.12.2018 International Filing Date: 30.05.2018
IPC:
G01N 33/569 (2006.01) ,G01N 33/53 (2006.01) ,G01N 33/50 (2006.01) ,G01N 33/543 (2006.01)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
569
for micro-organisms, e.g. protozoa, bacteria, viruses
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
543
with an insoluble carrier for immobilising immunochemicals
Applicants:
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA [US/US]; 1111 Franklin Street 12th Floor Oakland, California 94607-5200, US
Inventors:
KAMEI, Daniel, Takashi; US
WU, Benjamin, Ming; US
MOSLEY, Garrett, L.; US
CHIU, Yin, To; US
PEREIRA, David, Yuan; US
WU, Chloe, Michelle; US
HAN, Yue; US
LEE, So, Youn; US
Agent:
HUNTER, Tom; US
WEAVER, Jeffrey, K.; US
AUSTIN, James, E.; US
VILLENEUVE, Joseph, M.; US
SAMPSON, Roger, S.; US
GRIFFITH, John, F.; US
BERGIN, Denise, S.; US
SCHOLZ, Christian, D.; US
Priority Data:
62/513,34731.05.2017US
Title (EN) SINGLE-STEP ATPS ENHANCED LFA DIAGNOSTIC DESIGN
(FR) CONCEPTION DE DIAGNOSTIC LFA AMÉLIORÉ PAR ATPS À UNE ÉTAPE
Abstract:
(EN) In various embodiments single-step ATPS paper-based diagnostic assays are provided that exploit the concept of sequential resolubilization of ATPS components to give rise to the desired phase separation behavior within paper. In one illustrative embodiment, a wick is provided for concentrating an analyte within an aqueous two-phase extraction system in a paper, where the wick comprises a paper configured to receive a sample where the paper comprises a first region containing a first component of an aqueous two-phase system (ATPS) where the first component is in a dry form, and a second region containing a second component of an aqueous two-phase system (ATPS) where the second component is in a dry form; and where said first region and the second region are disposed so that when said wick is contacted with a fluid sample, the first component of said ATPS is hydrated before the second component. In certain embodiments the first and second component are disposed so they are hydrated substantially simultaneously.
(FR) Dans différents modes de réalisation, des dosages de diagnostic à base de papier ATPS à une étape qui exploitent le concept de resolubilisation séquentielle de composants ATPS pour conduire à un comportement de séparation de phase souhaité dans du papier. Dans un mode de réalisation illustratif, une mèche est fournie pour concentrer un analyte dans un système d’extraction à deux phases aqueuses dans un papier, la mèche comprenant un papier configuré pour recevoir un échantillon, le papier comprenant une première région contenant un premier composant d’un système à deux phases aqueuses (ATPS) dans lequel le premier composant est sous une forme sèche, et une deuxième région contenant un deuxième composant d’un système à deux phases aqueuses (ATPS), le deuxième composant étant sous une forme sèche ; et lorsque ladite première région et la deuxième région sont disposées de sorte que, lorsque ladite mèche est mise en contact avec un échantillon de fluide, le premier composant dudit ATPS est hydraté avant le second composant. Dans certains modes de réalisation, les premier et deuxième composants sont disposés de sorte qu’ils soient hydratés de façon sensiblement simultanée.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)