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1. (WO2018222741) BISPECIFIC ANTIBODIES FOR THE TREATMENT OF STREPTOCOCCUS PNEUMONIA

Pub. No.:    WO/2018/222741    International Application No.:    PCT/US2018/035170
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: A61K 39/395
A61K 39/40
C07K 16/12
G01N 33/569
Applicants: OKLAHOMA MEDICAL RESEARCH FOUNDATION
Inventors: SMITH, Kenneth
BRIGGS, Justin
Title: BISPECIFIC ANTIBODIES FOR THE TREATMENT OF STREPTOCOCCUS PNEUMONIA
Abstract:
The present disclosure relates generally to bispecific antibodies and functional fragments thereof that bind to at least two serotypes of streptococcus pneumonia. In particular, the disclosed bispecific antibodies and fragments can bind to serotypes 19A, 3, 22F, 6A, 6B, 6C, 19F, 15A, 23 A, 11 A, 35B, 12F, 22A and 7F of streptococcus pneumonia, and comprise novel complementarity determining regions (CDRs) also disclosed herein. The present disclosure further relates to treating streptococcus pneumonia infection by administering the disclosed bispecific antibodies to an individual with such an infection.