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1. (WO2018222723) C3 FUSION PROTEIN AND METHODS OF MAKING AND USING THEREOF
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Pub. No.: WO/2018/222723 International Application No.: PCT/US2018/035144
Publication Date: 06.12.2018 International Filing Date: 30.05.2018
IPC:
C12N 9/10 (2006.01) ,A61K 38/45 (2006.01)
[IPC code unknown for C12N 9/10][IPC code unknown for A61K 38/45]
Applicants:
VERTEX PHARMACEUTICALS INCORPORATED [US/US]; 50 Northern Avenue Boston, MA 02210, US
BIOAXONE BIOSCIENCES INCORPORATED [US/US]; 763 E Concord Avenue Cambridge, MA 02138, US
Inventors:
BORJAS, Ricardo; US
FLEMING, Mark; US
HUANG, Mei; US
JAIN, Mayur; US
SANGHVI, Tapan; US
SAXENA, Kumkum; US
TORRES-DELGADO, Amaris; US
YIN, Ping; US
MCKERRACHER, Lisa; US
RYU, Elizabeth; US
Agent:
CHEN, Fangli; US
SHALEK, James; US
CONSALVI, Mary; US
COUSINS, Abigail; US
BAUER, Steven; US
Priority Data:
62/512,66130.05.2017US
62/512,67330.05.2017US
62/512,69530.05.2017US
62/675,65923.05.2018US
62/675,68023.05.2018US
62/675,71423.05.2018US
Title (EN) C3 FUSION PROTEIN AND METHODS OF MAKING AND USING THEREOF
(FR) PROTÉINE DE FUSION C3 ET MÉTHODES DE FABRICATION ET D'UTILISATION DE CELLE-CI
Abstract:
(EN) The present invention provides, among other things, improved therapeutic compositions comprising a C3 fusion protein and methods of making and using the same. In particular, the present invention provides improved methods for the treatment of spinal cord injury and other CNS trauma and/or facilitate axon growth or other tissue repair.
(FR) La présente invention concerne, entre autres, des compositions thérapeutiques améliorées comprenant une protéine de fusion C3 et des méthodes de fabrication et d'utilisation de celles-ci. En particulier, la présente invention concerne des méthodes améliorées pour le traitement d'une lésion de la moelle épinière et d'autres traumatismes du SNC et/ou pour faciliter la croissance axonale ou d'autres réparations tissulaires.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)