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1. (WO2018222675) ANTI-DOUBLECORTIN-LIKE KINASE 1 ANTIBODIES AND METHODS OF USE

Pub. No.:    WO/2018/222675    International Application No.:    PCT/US2018/035071
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: A61K 6/00
A61K 45/06
A61K 45/00
A61K 39/395
A61K 39/00
A61K 47/00
Applicants: THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA
Inventors: HOUCHEN, Courtney, W.
WEYGANT, Nathaniel
QU, Dongfeng
MAY, Randal
CHANDRAKESAN, Parthasarathy
BERRY, William, L.
Title: ANTI-DOUBLECORTIN-LIKE KINASE 1 ANTIBODIES AND METHODS OF USE
Abstract:
Antibodies and antigen-binding fragments thereof that specifically bind to human DCLK1 protein, hybridomas or other cell lines which express such antibodies and antigen-binding fragments thereof, nucleic acids, vectors, and host cells comprising nucleic acids which encode such antibodies and antigen-binding fragments thereof, and methods of use thereof are disclosed. In at least certain non-limiting embodiments, the antibodies or antigen-binding fragments thereof specifically bind to an epitope within isoform 2 or 4 of DCLK1 protein.