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1. (WO2018222670) TREATMENT OF NEUROINFLAMMATORY DISEASE

Pub. No.:    WO/2018/222670    International Application No.:    PCT/US2018/035064
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: A61K 39/395
A61K 39/00
A61K 38/00
C07K 16/00
Applicants: THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY
Inventors: AJAMI, Bahareh
STEINMAN, Lawrence
Title: TREATMENT OF NEUROINFLAMMATORY DISEASE
Abstract:
Provided herein are methods and compositions for treating inflammatory diseases by administering to the subject an effective dose of an anti-alpha5 agent. Specifically, the methods are provided for the treatment of inflammatory diseases, including neuroinflammatory disease such as, neuroinflammatory demyelinating autoimmune diseases including multiple sclerosis (MS) and neuromyelitis optica (NMO), as well as the treatment of amyotrophic lateral sclerosis (ALS).