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1. (WO2018222665) METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING INFLAMMATORY DISEASES

Pub. No.:    WO/2018/222665    International Application No.:    PCT/US2018/035054
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: A61K 39/395
A61P 29/00
A61K 39/00
Applicants: ENTERIN LABORATORIES, INC.
Inventors: BARBUT, Denise
STOLZENBERG, Ethan
ZASLOFF, Michael
Title: METHODS AND COMPOSITIONS FOR PREVENTING OR TREATING INFLAMMATORY DISEASES
Abstract:
Described are methods of treating or preventing an inflammatory disease or condition caused by excessive expression, secretion, or concentration of alpha synuclein. The methods comprise administering compositions that reduce the effective concentration of alpha-synuclein present in the surrounding tissues. In addition, the invention encompasses methods of inhibiting alpha-synuclein interaction with CD11b, comprising administering an agent that binds to alpha-synuclein to prevent binding productively to the integrin CD11b, or administering an active agent that interacts with CD11b on an immune cell to prevent alpha-synuclein from directing chemotaxis of that cell. In addition, the invention discloses a method of identifying an individual with a condition amenable to treatment targeting alpha-synuclein CD11b interaction.