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1. (WO2018222655) METHODS OF TREATING FABRY PATIENTS HAVING RENAL IMPAIRMENT

Pub. No.:    WO/2018/222655    International Application No.:    PCT/US2018/035032
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: A61K 31/445
A61P 13/12
Applicants: AMICUS THERAPEUTICS, INC.
Inventors: CASTELLI, Jeff
Title: METHODS OF TREATING FABRY PATIENTS HAVING RENAL IMPAIRMENT
Abstract:
Provided are methods for treatment of Fabry disease in a patient having renal impairment and/or elevated proteinuria. Certain methods comprise administering to the patient about 100 to about 150 mg free base equivalent of migalastat or salt thereof at a frequency of once every other day. Certain methods also provide for the stabilization of renal function, reducing left ventricular mass index, reducing plasma globotriaosylsphingosine and/or increasing α-galactosidase A activity in the patient.