Search International and National Patent Collections

1. (WO2018222607) VIABLE VIRUSES WITH FOREIGN TAGS

Pub. No.:    WO/2018/222607    International Application No.:    PCT/US2018/034917
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: A61K 39/12
A61K 39/39
A61P 31/12
A61K 39/00
Applicants: THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY OF AGRICULTURE
Inventors: FAABERG, Kay S.
SPEAR, Allyn
KAPPES, Matthew A.
LAGER, Kelly M.
Title: VIABLE VIRUSES WITH FOREIGN TAGS
Abstract:
Multiple DIVA vaccines effective against porcine reproductive and respiratory syndrome virus (PRRSV) are disclosed. The DIVA vaccines may be negative DIVAs or positive DIVAs. The DIVA vaccines may be produced by modifying the nsp2 region of a modified live virus vaccine. The modification may be one or more deletions only (negative DIVAs) or a deletion with an insertion (positive DIVAs). The insertion may be of an epitope tag, such as a V5, S-Tag, or FLAG tag. Produced DIVA vaccines may be stable through multiple passes and thus may be effective for production and vaccination of animals.