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1. (WO2018222601) 5-5 FUSED RINGS AS C5a INHIBITORS

Pub. No.:    WO/2018/222601    International Application No.:    PCT/US2018/034908
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: C07D 487/04
Applicants: CHEMOCENTRYX, INC.
Inventors: FAN, Pingchen
LANGE, Christopher W.
LUI, Rebecca M.
MALATHONG, Viengkham
MALI, Venkat Reddy
PUNNA, Sreenivas
ZENG, Yibin
ZHANG, Penglie
Title: 5-5 FUSED RINGS AS C5a INHIBITORS
Abstract:
The present disclosure provides, inter alia, Compounds of Formula (I) (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.