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1. (WO2018222598) 6-5 FUSED RINGS AS C5a INHIBITORS
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Pub. No.: WO/2018/222598 International Application No.: PCT/US2018/034905
Publication Date: 06.12.2018 International Filing Date: 29.05.2018
IPC:
C07D 487/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
487
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/-C07D477/183
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
CHEMOCENTRYX, INC. [US/US]; 850 Maude Avenue Mountain View, California 94043, US
Inventors:
FAN, Pingchen; US
LANGE, Christopher W.; US
LUI, Rebecca M.; US
MALATHONG, Viengkham; US
MALI, Venkat Reddy; US
PUNNA, Sreenivas; US
SINGH, Rajinder; US
TANAKA, Hiroko; US
ZENG, Yibin; US
ZHANG, Penglie; US
Agent:
KEZER, William; US
TRIMBLE, Alexander R.; US
DOLAN, Gregory F.; US
Priority Data:
62/513,01031.05.2017US
Title (EN) 6-5 FUSED RINGS AS C5a INHIBITORS
(FR) CYCLES 6-5 FUSIONNÉS UTILISÉS EN TANT QU'INHIBITEURS DE C5A
Abstract:
(EN) The present disclosure provides, inter alia, Compounds of Formula (I) (I) or pharmaceutically acceptable salts thereof that are modulators of the C5a receptor. Also provided are pharmaceutical compositions and methods of use including the treatment of diseases or disorders involving pathologic activation from C5a and non-pharmaceutical applications.
(FR) La présente invention concerne, entre autres, des composés de formule (I) ou des sels pharmaceutiquement acceptables de ceux-ci qui sont des modulateurs du récepteur C5a. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation comprenant le traitement de maladies ou de troubles impliquant une activation pathologique à partir d'applications de C5a et d'applications non-pharmaceutiques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)