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1. (WO2018222593) FUNCTIONLIZED CALIBRANTS FOR SPECTROMETRY AND CHROMATOGRAPHY

Pub. No.:    WO/2018/222593    International Application No.:    PCT/US2018/034885
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: G01N 33/00
H01J 49/00
G01N 27/62
B01D 15/34
G01N 30/86
Applicants: THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND
Inventors: GRAYSON, Scott, M.
Title: FUNCTIONLIZED CALIBRANTS FOR SPECTROMETRY AND CHROMATOGRAPHY
Abstract:
Calibrants and methods of making the same include using mixtures of multifunctional core compounds or multifunctional dendrimers that are functionalized to yield a set of discrete compounds which cover a range of collisional cross sections (CCSs) for calibrating ion mobility and variation in molecular weight to calibrate the mass to charge (m/z) measurements of mass spectrometry, as well as for calibrating tandem instruments that measure both dimensions. Methods of using the calibrants are also disclosed, such as in mass spectrometry.