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1. (WO2018222585) SINGLE MOLECULE DETECTION AND QUANTIFICATION OF NUCLEIC ACIDS WITH SINGLE BASE SPECIFICITY
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Pub. No.: WO/2018/222585 International Application No.: PCT/US2018/034870
Publication Date: 06.12.2018 International Filing Date: 29.05.2018
IPC:
C12Q 1/6886 (2018.01) ,G01N 33/53 (2006.01)
[IPC code unknown for C12Q 1/6886][IPC code unknown for G01N 33/53]
Applicants:
QUANTERIX CORPORATION [US/US]; 113 Hartwell Avenue Lexington, MA 02421-3125, US
DESTINA GENOMICS LTD [GB/GB]; 7-11 Melville St. Edinburgh, EH3 7PE, GB
Inventors:
DIAZ-MOCHON, Juan, J.; ES
DUFFY, David, C.; US
PERNAGALLO, Salvatore; ES
ILYINE, Hugh; GB
RISSIN, David, M.; US
LOPEZ-LONGARELA, Barbara; ES
Agent:
CHEN, Yahua; US
Priority Data:
62/512,45030.05.2017US
Title (EN) SINGLE MOLECULE DETECTION AND QUANTIFICATION OF NUCLEIC ACIDS WITH SINGLE BASE SPECIFICITY
(FR) DÉTECTION ET QUANTIFICATION DE MOLÉCULES UNIQUES D'ACIDES NUCLÉIQUES À SPÉCIFICITÉ DE BASE UNIQUE
Abstract:
(EN) Methods for detecting nucleic acids, particularly small nucleic acids such as microRNAs, involving the use of a peptide nucleic acid (PNA) probe that lacks a base and a labelled modified base corresponding to the omitted base in the PNA probe. A complex containing the target nucleic acid, the PNA probe, and the modified base can be determined using a single molecule array assay.
(FR) L'invention concerne des procédés de détection d'acides nucléiques, en particulier de petits acides nucléiques tels que des micro-ARN, comprenant l'utilisation d'une sonde d'acide nucléique peptidique (PNA) dépourvue d'une base et d'une base modifiée marquée correspondant à la base omise dans la sonde PNA. Un complexe contenant l'acide nucléique cible, la sonde PNA et la base modifiée peuvent être déterminés au moyen d'un dosage à matrice de molécules uniques.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)