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1. (WO2018222578) IMMUNOMODULATING TRANSGENIC PLANTS AND RELATED METHODS
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Pub. No.: WO/2018/222578 International Application No.: PCT/US2018/034856
Publication Date: 06.12.2018 International Filing Date: 29.05.2018
IPC:
A01H 5/00 (2018.01) ,A61K 38/20 (2006.01) ,C07K 14/54 (2006.01) ,C07K 16/02 (2006.01) ,A61K 39/395 (2006.01) ,C07K 16/24 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
H
NEW PLANTS OR PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
5
Flowering plants, i.e. angiosperms
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
19
Cytokines; Lymphokines; Interferons
20
Interleukins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
52
Cytokines; Lymphokines; Interferons
54
Interleukins (IL)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
02
from eggs
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18
against material from animals or humans
24
against cytokines, lymphokines or interferons
Applicants:
AGRIVIDA, INC. [US/US]; 78E Olympia Avenue Woburn, Massachusetts 01801, US
Inventors:
RAAB, R. Michael; US
BOUGRI, Oleg; US
PARKER, Matthew; US
LESSARD, Philip A.; US
Agent:
SIGAREVA, Marina A.; US
Priority Data:
62/512,44430.05.2017US
Title (EN) IMMUNOMODULATING TRANSGENIC PLANTS AND RELATED METHODS
(FR) PLANTES TRANSGÉNIQUES IMMUNOMODULATRICES ET PROCÉDÉS ASSOCIÉS
Abstract:
(EN) The transgenic plants expressing one or more antagonist IL-10R peptides and anti-IL-10 single domain antibodies that stimulate or modulate the immune system and improve gastrointestinal physiology of an animal fed the transgenic plants or tissues thereof and the genes encoding the antagonist IL-10R peptides and anti-IL-10 single domain antibodies are described. The animal feed additives and animal feed incorporating the transgenic plants or tissues thereof are also described. Methods of stimulating or modulating an animal's immune system, improving an animal's gastrointestinal physiology, improving animal performance by using the transgenic plants or tissues thereof, and treating animals infected with a gastrointestinal pathogen are provided.
(FR) L'invention concerne les plantes transgéniques exprimant un ou plusieurs peptides IL-10R antagonistes et des anticorps anti-IL-10 à domaine unique qui stimulent ou modulent le système immunitaire et améliorent la physiologie gastro-intestinale d'un animal nourri avec les plantes transgéniques ou des tissus de celles-ci, ainsi que les gènes codant pour les peptides IL-10R antagonistes et les anticorps anti-IL-10 à domaine unique. L'invention concerne également des additifs alimentaires et des aliments pour animaux incorporant les plantes transgéniques ou des tissus de celles-ci. L'invention concerne également des procédés de stimulation ou de modulation du système immunitaire d'un animal, d'amélioration de la physiologie gastro-intestinale d'un animal, d'amélioration des performances d'un animal à l'aide des plantes transgéniques ou de leurs tissus, et de traitement d'animaux infectés par un agent pathogène gastro-intestinal.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)