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1. (WO2018222573) RECOMBINANT CHIMERIC BOVINE/HUMAN PARAINFLUENZA VIRUS 3 EXPRESSING RSV G AND ITS USE
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Pub. No.: WO/2018/222573 International Application No.: PCT/US2018/034848
Publication Date: 06.12.2018 International Filing Date: 29.05.2018
IPC:
A61K 39/155 (2006.01) ,C07K 14/115 (2006.01)
[IPC code unknown for A61K 39/155][IPC code unknown for C07K 14/115]
Applicants:
THE UNITED STATE OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES [US/US]; National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325, MSC 7660 Bethesda, MD 20892, US
Inventors:
COLLINS, Peter, L.; US
BUCHHOLZ, Ursula, J.; US
LIANG, Bo; US
MUNIR, Shirin; US
Agent:
SCOTT, Gregory, K.; US
Priority Data:
62/512,11129.05.2017US
Title (EN) RECOMBINANT CHIMERIC BOVINE/HUMAN PARAINFLUENZA VIRUS 3 EXPRESSING RSV G AND ITS USE
(FR) VIRUS PARAINFLUENZA BOVIN/HUMAIN CHIMÈRE RECOMBINANT DE TYPE 3 EXPRIMANT LA RSV G ET SON UTILISATION
Abstract:
(EN) Recombinant chimeric bovine/human parainfluenza virus 3 (rB/HPIV3) vectors expressing Respiratory Syncytial Virus (RSV) G protein or a recombinant RSV G protein, as well as methods of their use and manufacture, are provided. The rB/HPIV3 vector comprises a genome comprising a heterologous gene encoding the RSV G protein or the recombinant RSV G protein. Nucleic acid molecules comprising the sequence of the genome or antigenome of the disclosed rB/HPIV3 vectors are also provided. The disclosed rB/HPIV3 vectors can be used, for example, to induce an immune response to RSV and HPIV3 in a subject.
(FR) La présente invention concerne des vecteurs du virus parainfluenza bovin/humain chimère recombinant de type 3 (rB/HPIV3) exprimant la protéine G du virus respiratoire syncytial (RSV) ou une protéine RSV G recombinante, ainsi que des procédés destinés à leur utilisation et à leur fabrication. Le vecteur rB/HPIV3 comprend un génome comprenant un gène hétérologue codant pour la protéine RSV G ou la protéine RSV G recombinante. L’invention concerne également des molécules d’acide nucléique comprenant la séquence du génome ou de l’antigénome des vecteurs rB/HPIV3. Les vecteurs rB/HPIV3 selon l'invention peuvent être utilisés, par exemple, pour induire une réponse immunitaire au RSV et au HPIV3 chez un sujet.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)