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1. (WO2018222549) NOVEL DEUTERIUM SUBSTITUTED POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS AND THEIR PHARMACOLOGICAL APPLICATION
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Pub. No.: WO/2018/222549 International Application No.: PCT/US2018/034691
Publication Date: 06.12.2018 International Filing Date: 25.05.2018
IPC:
C07D 455/06 (2006.01) ,C07F 7/10 (2006.01)
[IPC code unknown for C07D 455/06][IPC code unknown for C07F 7/10]
Applicants:
FIVE ELEVEN PHARMA INC. [US/US]; 3700 Market St. Suite 305 Philadelphia, Pennsylvania 19104, US
Inventors:
WU, Zehui; US
ZHA, Zhihao; US
LIU, Futao; US
PLOESSL, Karl; US
CHOI, Seok Rye; US
KUNG, Hank F.; US
Agent:
COVERT, John M.; US
BEZOS, Salvador M.; US
BODENSTEIN, Matthew; US
CALVO, Paul A.; US
CAMARCE, Christian; US
CIMBALA, Michelle A.; US
COLLER III, Richard D.; US
CONKLIN, Kyle; US
CORNWELL, David K.S.; US
DURKIN, Tracy-Gene G.; US
EISENBERG, Jason D.; US
ELLISON, Eldora L.; US
ESMOND, Robert W.; US
FEATHERSTONE, Donald J.; US
FRUEAUF, Jeremiah B.; US
GAJEWSKI, Daniel; US
GOLDSTEIN, Jorge A.; US
HELVEY, Jeffrey T.; US
HICKS, Ross; US
HOLOUBEK, Michelle K.; US
JACKMAN, Peter A.; US
KIM, Ji-Eun; US
LEE, Michael Q.; US
LONGSWORTH, Gaby L.; US
MILLONIG, Robert C.; US
MUTSCHELKNAUS, Joseph; US
NANNENGA-COMBS, Bonnie; US
PICKARD, Byron L.; US
POWERS, Trey; US
RAY, Michael B.; US
ROSE GILLENTINE, Marsha; US
RYGIEL, Mark W.; US
SHEA, JR., Timothy J.; US
SOKOHL, Robert E.; US
SPECHT, Michael D.; US
STEFFE, Eric K.; US
STERLING, Deborah A.; US
STERNE, Robert Greene; US
TUMINARO, Jonathan; US
WRIGHT, Jon E.; US
Priority Data:
62/513,21731.05.2017US
Title (EN) NOVEL DEUTERIUM SUBSTITUTED POSITRON EMISSION TOMOGRAPHY (PET) IMAGING AGENTS AND THEIR PHARMACOLOGICAL APPLICATION
(FR) NOUVEAUX AGENTS D'IMAGERIE PAR TOMOGRAPHIE PAR ÉMISSION DE POSITRONS (PET) SUBSTITUÉS PAR DU DEUTÉRIUM ET LEUR APPLICATION PHARMACOLOGIQUE
Abstract:
(EN) The present invention relates to deuterated compounds according to Formula I-A, Formula II-A, Formula II-D, and Formula III-A. These compounds can be used as PET imaging agents for evaluating Parkinson's Disease, Alzheimer Disease, and for determining specific serotonin reuptake inhibitor (SSRIi) activity for treatment of depression. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I-A, Formulae II-A, Formula II-D, or Formula III-A, or a pharmaceutically acceptable salt thereof.
(FR) La présente invention concerne des composés deutérés selon la formule I-A, formule II-A, formule II-D, et la formule III-A. Ces composés peuvent être utilisés en tant qu'agents d'imagerie TEP pour évaluer la maladie de Parkinson, la maladie d'Alzheimer et pour déterminer l'activité d'inhibiteur spécifique de la recapture de la sérotonine (SSRIi) pour le traitement de la dépression. La présente invention concerne également des compositions pharmaceutiques comprenant un véhicule pharmaceutiquement acceptable et un composé de formule I-A, formules II-A, formule II-D ou formule III-A, ou un sel pharmaceutiquement acceptable de celui-ci.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)