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1. (WO2018222506) MODULATION OF IMMUNOGLOBULIN-A-POSITIVE CELLS

Pub. No.:    WO/2018/222506    International Application No.:    PCT/US2018/034526
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat May 26 01:59:59 CEST 2018
IPC: C07K 16/00
C07K 16/18
C07K 16/42
C07K 16/46
Applicants: IMMUNE-ONC THERAPEUTICS, INC.
Inventors: LIAO, X. Charlene
LIU, Qiang
HUANG, Tao
ZHOU, Jianhui
Title: MODULATION OF IMMUNOGLOBULIN-A-POSITIVE CELLS
Abstract:
Provided are compositions and methods for modulating, such as depleting, reducing, blocking the activation or immunosuppressive function of immunoglobulin-A (IgA)-producing cells. Also provided are methods for treating an IgA-associated condition, such as cancer, in a subject. In one embodiment, the method includes administering to the subject a therapeutically effective amount of an antibody or the antigen-binding fragment thereof specific to membrane-anchored IgA. Methods for preventing, detecting or diagnosing cancer in a subject with immunosuppressive microenvironment are also provided.