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1. (WO2018222432) A PREDICTIVE BIOMARKER FOR LET-7 MICRORNA-BASED THERAPEUTICS FOR THE TREATMENT OF HUMAN CANCER
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Pub. No.: WO/2018/222432 International Application No.: PCT/US2018/033670
Publication Date: 06.12.2018 International Filing Date: 21.05.2018
IPC:
A61P 35/00 (2006.01) ,C12N 15/113 (2010.01) ,C12Q 1/68 (2018.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
113
Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
YANG, Dun [US/US]; US
ZHANG, Jing [GB/GB]; GB
ZHANG, Shenqiu [GB/GB]; GB
Inventors:
YANG, Dun; US
ZHANG, Jing; GB
ZHANG, Shenqiu; GB
Agent:
ROBINSON, Edward, D.; US
Priority Data:
62/511,99327.05.2017US
Title (EN) A PREDICTIVE BIOMARKER FOR LET-7 MICRORNA-BASED THERAPEUTICS FOR THE TREATMENT OF HUMAN CANCER
(FR) BIOMARQUEUR PRÉDICTIF POUR AGENTS THÉRAPEUTIQUES À BASE DE MICROARN LET-7 POUR LE TRAITEMENT DU CANCER HUMAIN
Abstract:
(EN) The disclosure provides methods for suppressing BRAF-driven tumorigenesis by administering one or more lethal-7 miRNA-based therapeutics to a patient in need thereof. The disclosure also provides methods for treating cancer that has an active BRAF oncogene by administering one or more lethal-7 miRNA-based therapeutics to a patient in need thereof. The disclosure further provides methods for predicting favorable treatment responses to lethal-7 microRNA-based therapeutics by administering one or more lethal-7 miRNA-based therapeutics to a patient in need thereof; and monitoring active BRAF signaling for predicting favorable treatment responses in the patient.
(FR) La présente divulgation concerne des méthodes de suppression de tumorigenèse induite par BRAF par administration d'un ou de plusieurs agents thérapeutiques à base d'ARNmi létal-7 à un patient en ayant besoin. La divulgation concerne également des méthodes de traitement de cancer à oncogène BRAF actif par administration d'un ou de plusieurs agents thérapeutiques à base d'ARNmi létal-7 à un patient en ayant besoin. Des méthodes de prédiction de réponses thérapeutiques favorables à des agents thérapeutiques à base de microARN létal-7 par administration d'un ou de plusieurs agents thérapeutiques à base d'ARNmi létal-7 à un patient en ayant besoin ; et la surveillance de la signalisation de BRAF actif pour prédire des réponses thérapeutiques favorables chez le patient sont en outre décrites.
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)