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1. (WO2018222363) SYSTEMS AND METHODS FOR PATIENT SPECIFIC MODELING OF THE MECHANICAL PROPERTIES OF BONE

Pub. No.:    WO/2018/222363    International Application No.:    PCT/US2018/031981
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri May 11 01:59:59 CEST 2018
IPC: A61B 5/00
G06F 9/455
Applicants: OHIO UNIVERSITY
Inventors: BOWMAN, Lyn
COTTON, John R.
Title: SYSTEMS AND METHODS FOR PATIENT SPECIFIC MODELING OF THE MECHANICAL PROPERTIES OF BONE
Abstract:
Methods of patient-specific modeling of the mechanical properties of bone and related systems. The methods include obtaining a bending stiffness (K) of a bone specimen non-invasively and non-destructively in a dynamic 3-point bending test, creating a mathematical mechanical model of the bone specimen, assigning an elastic modulus (E) to the bone specimen of the mathematical mechanical model, determining the flexural rigidity of the bone specimen from simulating the mathematical mechanical model, determining a discrepancy between the flexural rigidity of the bone specimen from the simulated mechanical model and based on the obtained K, adjusting the elastic modulus of the simulated mechanical model to minimize the discrepancy, adjusting the elastic modulus until an optimized elastic modulus is determined where the discrepancy is reduced below a predetermined threshold, and applying the optimized elastic modulus to the simulated mechanical model to determine a strength of the bone.