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1. (WO2018222351) TRIPTOLIDE LACTONE DERIVATIVES AS IMMUNOMODULATORS AND ANTICANCER AGENTS

Pub. No.:    WO/2018/222351    International Application No.:    PCT/US2018/031598
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 09 01:59:59 CEST 2018
IPC: C07D 493/22
A61K 31/343
A61K 31/336
A61P 35/00
Applicants: PHARMAGENESIS, INC.
Inventors: MUSSER, John H.
Title: TRIPTOLIDE LACTONE DERIVATIVES AS IMMUNOMODULATORS AND ANTICANCER AGENTS
Abstract:
Disclosed herein are triptolide derivative compounds, and compositions comprising said compounds, as well as methods of making and methods of using said compounds and compositions, which are medicinally and pharmaceutically useful as antiproliferative, anticancer and immunosuppressive therapeutics.