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1. (WO2018222061) IMPROVED THERAPEUTIC DRUG MONITORING

Pub. No.:    WO/2018/222061    International Application No.:    PCT/PT2018/050021
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: C12Q 1/18
G01N 33/58
Applicants: FASTINOV S.A.
Inventors: AZEVEDO PINA VAZ, Cidalia Irene
GONCALVES RODRIGUES, Acácio Agostinho
Title: IMPROVED THERAPEUTIC DRUG MONITORING
Abstract:
Disclosed herein are methods and compositions for antimicrobial quantification and functional measurement. In one aspect, a method for quantifying antimicrobial comprises: obtaining a biological sample from a patient receiving an antimicrobial; incubating the biological sample with a reference microbial strain and a fluorophore for detecting cell lesion; measuring a first signal of fluorescent intensity in the incubated biological sample using flow cytometry; and comparing the first signal to a calibrating curve previously generated for the antimicrobial, thereby quantifying the antimicrobial present in the biological sample.