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1. (WO2018221735) NOVEL OLIGONUCLEOTIDES
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Pub. No.: WO/2018/221735 International Application No.: PCT/JP2018/021246
Publication Date: 06.12.2018 International Filing Date: 01.06.2018
IPC:
C12N 15/11 (2006.01) ,A61K 31/711 (2006.01) ,A61P 35/00 (2006.01) ,A61P 35/04 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7088
Compounds having three or more nucleosides or nucleotides
711
Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
04
specific for metastasis
Applicants:
富田製薬株式会社 TOMITA PHARMACEUTICAL CO., LTD. [JP/JP]; 徳島県鳴門市瀬戸町明神字丸山85番地1 85-1, Aza-Maruyama, Akinokami, Seto-cho, Naruto-shi, Tokushima 7710360, JP
Inventors:
渡邉 貞佳 WATANABE, Sadayoshi; JP
中瀬 博 NAKASE, Hiroshi; JP
中村 順一郎 NAKAMURA, Junichiro; JP
Agent:
田中 順也 TANAKA, Junya; JP
水谷 馨也 MIZUTANI, Keiya; JP
Priority Data:
2017-11047302.06.2017JP
Title (EN) NOVEL OLIGONUCLEOTIDES
(FR) NOUVEAUX OLIGONUCLÉOTIDES
(JA) 新規オリゴヌクレオチド
Abstract:
(EN) The purpose of the present invention is to provide novel nucleic acids having antitumor activity. Oligonucleotides comprising base sequences represented by SEQ ID NO: 1-6 exhibit a growth inhibitory action against cancer cells but do not affect normal cells, and thus are useful as anticancer agents.
(FR) L'objet de la présente invention est de fournir de nouveaux acides nucléiques présentant une activité antitumorale. Les oligonucléotides comprenant des séquences de bases telles que représentées par les SEQ ID No : 1 à 6 présentent une action inhibitrice de la croissance contre les cellules cancéreuses, mais n'affectent pas les cellules normales, et sont ainsi utiles en tant qu'agents anticancéreux.
(JA) 本発明の目的は、抗がん作用を有する新規核酸を提供することである。 配列番号1~6に示す塩基配列からなるオリゴヌクレオチドは、がん細胞に対する増殖阻害作用があり、しかも正常細胞に対しては影響を与えないため、抗がん剤として有効である。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)