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1. (WO2018221732) AMYLOID-β PROTEIN LEVEL DECREASING AGENT

Pub. No.:    WO/2018/221732    International Application No.:    PCT/JP2018/021226
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: A61K 31/397
A61P 25/28
Applicants: FUJIFILM TOYAMA CHEMICAL CO., LTD.
富士フイルム富山化学株式会社
Inventors: KOBAYASHI Hiroshi
小林 博
MATSUMOTO Yoshihiko
松本 喜彦
Title: AMYLOID-β PROTEIN LEVEL DECREASING AGENT
Abstract:
The present invention addresses the problem of providing a pharmaceutical agent and a method for suppressing the progression of diseases such as Alzheimer-type dementia indicating an increase in the level of amyloid-β protein in the brain. 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof has an effect of decreasing the level of amyloid-β protein in the brain parenchyma, and hence is effective as an agent for decreasing the level of amyloid-β protein in the brain. By administering 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof, it is possible to prevent or treat diseases in which an increase in the level of amyloid-β protein in the brain occurs, such as Alzheimer-type dementia.