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1. (WO2018221728) AGENT FOR PREVENTING OR TREATING ALZHEIMER-TYPE DEMENTIA
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Pub. No.: WO/2018/221728 International Application No.: PCT/JP2018/021222
Publication Date: 06.12.2018 International Filing Date: 01.06.2018
IPC:
A61K 31/397 (2006.01) ,A61P 25/28 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
397
having four-membered rings, e.g. azetidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
28
for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Applicants:
富士フイルム富山化学株式会社 FUJIFILM TOYAMA CHEMICAL CO., LTD. [JP/JP]; 東京都中央区京橋二丁目14番1号 14-1, Kyobashi 2-chome, Chuo-ku, Tokyo 1040031, JP
Inventors:
小林 博 KOBAYASHI Hiroshi; JP
松本 喜彦 MATSUMOTO Yoshihiko; JP
Agent:
特許業務法人特許事務所サイクス SIKS & CO.; 東京都中央区京橋一丁目8番7号 京橋日殖ビル8階 8th Floor, Kyobashi-Nisshoku Bldg., 8-7, Kyobashi 1-chome, Chuo-ku, Tokyo 1040031, JP
Priority Data:
2017-10988702.06.2017JP
Title (EN) AGENT FOR PREVENTING OR TREATING ALZHEIMER-TYPE DEMENTIA
(FR) AGENT POUR PRÉVENIR OU TRAITER LA DÉMENCE DE TYPE ALZHEIMER
(JA) アルツハイマー型認知症予防または治療剤
Abstract:
(EN) The present invention addresses the problem of providing: an agent for suppressing the progression of Alzheimer-type dementia; and a method for suppressing the progression of Alzheimer-type dementia. According to the present invention, it is possible to effectively prevent or treat Alzheimer-type dementia by starting administration of a pharmaceutical composition containing 1-(3-(2-(1-benzothiophen-5-yl)ethoxy)propyl)azetidin-3-ol or a salt thereof as an active ingredient to a patient within a certain period of time after that patient has been clinically diagnosed with Alzheimer-type dementia.
(FR) La présente invention aborde le problème consistant à fournir : un agent pour supprimer la progression de la démence de type Alzheimer ; et un procédé pour supprimer la progression de la démence de type Alzheimer. Selon la présente invention, il est possible de prévenir ou de traiter efficacement la démence de type Alzheimer par le démarrage de l'administration d'une composition pharmaceutique contenant du 1-(3-(2-(1-benzothiophén-5-yl)éthoxy)propyl)azétidin-3-ol ou un sel de celui-ci en tant que principe actif à un patient dans une certaine période de temps après que le patient a été cliniquement diagnostiqué comme souffrant de démence de type Alzheimer.
(JA) 本発明の課題は、アルツハイマー型認知症の進行を抑制する薬剤およびアルツハイマー型認知症の進行を抑制する方法を提供することである。1-(3-(2-(1-ベンゾチオフェン-5-イル)エトキシ)プロピル)アゼチジン-3-オールまたはその塩を有効成分として含有する医薬組成物を、アルツハイマー型認知症の臨床診断時から一定期間以内の患者に投与開始することにより、アルツハイマー型認知症を効果的に予防または治療できる。
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)