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1. WO2018221402 - METHOD FOR PRODUCING DECELLULARIZED MATERIAL FOR TRANSPLANTATION AND GRAFT COMPOSITION COMPRISING BIOCOMPATIBLE MATERIAL INCLUDING SAID MATERIAL

Publication Number WO/2018/221402
Publication Date 06.12.2018
International Application No. PCT/JP2018/020141
International Filing Date 25.05.2018
IPC
A61L 27/36 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for prostheses or for coating prostheses
36containing ingredients of undetermined constitution or reaction products thereof
A61F 2/06 2013.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
06Blood vessels
CPC
A61F 2/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02Prostheses implantable into the body
04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
06Blood vessels
A61L 2430/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2430Materials or treatment for tissue regeneration
40Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
A61L 27/36
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
A61L 27/3625
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3604characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
3625Vascular tissue, e.g. heart valves
A61L 27/3691
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
36containing ingredients of undetermined constitution or reaction products thereof ; , e.g. transplant tissue, natural bone, extracellular matrix
3683subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
3691characterised by physical conditions of the treatment, e.g. applying a compressive force to the composition, pressure cycles, ultrasonic/sonication or microwave treatment, lyophilisation
A61L 27/507
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27Materials for ; grafts or; prostheses or for coating ; grafts or; prostheses
50Materials characterised by their function or physical properties ; , e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
507for artificial blood vessels
Applicants
  • 株式会社ADEKA ADEKA CORPORATION [JP]/[JP]
Inventors
  • 樋上 哲哉 HIGAMI, Tetsuya
  • 日渡 謙一郎 HIWATARI, Kenichiro
  • 山口 雄 YAMAGUCHI, Yu
  • 小原 春樹 OBARA, Haruki
  • 木村 拓矢 KIMURA, Takuya
  • 本間 光将 HOMMA, Mitsumasa
  • 落合 恭平 OCHIAI, Kyohei
  • 木下 敬太 KINOSHITA, Keita
  • 森本 奈保喜 MORIMOTO, Naoki
Agents
  • 曾我 道治 SOGA, Michiharu
  • 梶並 順 KAJINAMI, Jun
  • 大宅 一宏 OHYA, Kazuhiro
Priority Data
2017-10640030.05.2017JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) METHOD FOR PRODUCING DECELLULARIZED MATERIAL FOR TRANSPLANTATION AND GRAFT COMPOSITION COMPRISING BIOCOMPATIBLE MATERIAL INCLUDING SAID MATERIAL
(FR) PROCÉDÉ DE PRODUCTION DE MATÉRIAU DÉCELLULARISÉ POUR TRANSPLANTATION ET COMPOSITION DE GREFFE COMPRENANT UN MATÉRIAU BIOCOMPATIBLE COMPRENANT LEDIT MATÉRIAU
(JA) 移植用脱細胞化材料の製造方法及び当該材料を含む生体適合性材料からなる移植片組成物
Abstract
(EN)
The purpose of the present invention is to provide a method for producing a decellularized material for transplantation that can be used in a graft composition and minimizes the portion sutured by thread. To achieve the above purpose, the present invention provides a method for producing a decellularized material for transplantation that includes (a) a step for collecting a branched blood vessel from a vertebrate animal (donor), (b) a step for decellularizing the blood vessel, and (c) a step for adhering the portion from which the branch has been excised by protein denaturation treatment and closing the vessel. The present invention also provides a graft composition comprising a biocompatible material that includes the decellularized material for transplantation.
(FR)
L'objectif de la présente invention est de fournir un procédé de production d'un matériau décellularisé pour transplantation qui peut être utilisé dans une composition de greffe et réduit au minimum la partie suturée par fil. Afin de réaliser l'objectif ci-dessus, la présente invention concerne un procédé de production d'un matériau décellularisé pour transplantation qui comprend (a) une étape de collecte d'un vaisseau sanguin de branchement à partir d'un animal vertébré (donneur), (b) une étape de décellularisation du vaisseau sanguin, et (c) une étape d'adhésion de la partie à partir de laquelle la ramification a été excisée par un traitement de dénaturation de protéine et de fermeture du vaisseau. La présente invention concerne en outre une composition de greffe comprenant un matériau biocompatible qui comprend le matériau décellularisé pour une transplantation.
(JA)
移植片組成物に利用可能な、糸による縫合部を最小限に抑えた移植用脱細胞化材料を製造する方法を提供することを目的とする。 上記目的を達成するため、本発明は(a)脊椎動物(ドナー)から分枝を有する血管を採取する工程、(b)当該血管を脱細胞化する工程、及び(c)分枝を切除した部分をタンパク質変性処理により接着し閉管する工程を含む、移植用脱細胞化材料の製造方法を提供する。さらに、本発明は当該移植用脱細胞化材料を含む生体適合性材料からなる移植片組成物も提供する。
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