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1. (WO2018221402) METHOD FOR PRODUCING DECELLULARIZED MATERIAL FOR TRANSPLANTATION AND GRAFT COMPOSITION COMPRISING BIOCOMPATIBLE MATERIAL INCLUDING SAID MATERIAL
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Pub. No.: WO/2018/221402 International Application No.: PCT/JP2018/020141
Publication Date: 06.12.2018 International Filing Date: 25.05.2018
IPC:
A61L 27/36 (2006.01) ,A61F 2/06 (2013.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
36
containing ingredients of undetermined constitution or reaction products thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
F
FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, E.G. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
2
Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
02
Prostheses implantable into the body
04
Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
06
Blood vessels
Applicants:
樋上 哲哉 HIGAMI, Tetsuya [JP/JP]; JP
Inventors:
樋上 哲哉 HIGAMI, Tetsuya; JP
日渡 謙一郎 HIWATARI, Kenichiro; JP
山口 雄 YAMAGUCHI, Yu; JP
小原 春樹 OBARA, Haruki; JP
木村 拓矢 KIMURA, Takuya; JP
本間 光将 HOMMA, Mitsumasa; JP
落合 恭平 OCHIAI, Kyohei; JP
木下 敬太 KINOSHITA, Keita; JP
森本 奈保喜 MORIMOTO, Naoki; JP
Agent:
曾我 道治 SOGA, Michiharu; JP
梶並 順 KAJINAMI, Jun; JP
大宅 一宏 OHYA, Kazuhiro; JP
Priority Data:
2017-10640030.05.2017JP
Title (EN) METHOD FOR PRODUCING DECELLULARIZED MATERIAL FOR TRANSPLANTATION AND GRAFT COMPOSITION COMPRISING BIOCOMPATIBLE MATERIAL INCLUDING SAID MATERIAL
(FR) PROCÉDÉ DE PRODUCTION DE MATÉRIAU DÉCELLULARISÉ POUR TRANSPLANTATION ET COMPOSITION DE GREFFE COMPRENANT UN MATÉRIAU BIOCOMPATIBLE COMPRENANT LEDIT MATÉRIAU
(JA) 移植用脱細胞化材料の製造方法及び当該材料を含む生体適合性材料からなる移植片組成物
Abstract:
(EN) The purpose of the present invention is to provide a method for producing a decellularized material for transplantation that can be used in a graft composition and minimizes the portion sutured by thread. To achieve the above purpose, the present invention provides a method for producing a decellularized material for transplantation that includes (a) a step for collecting a branched blood vessel from a vertebrate animal (donor), (b) a step for decellularizing the blood vessel, and (c) a step for adhering the portion from which the branch has been excised by protein denaturation treatment and closing the vessel. The present invention also provides a graft composition comprising a biocompatible material that includes the decellularized material for transplantation.
(FR) L’objectif de la présente invention est de fournir un procédé de production d’un matériau décellularisé pour transplantation qui peut être utilisé dans une composition de greffe et réduit au minimum la partie suturée par fil. Afin de réaliser l’objectif ci-dessus, la présente invention concerne un procédé de production d’un matériau décellularisé pour transplantation qui comprend (a) une étape de collecte d’un vaisseau sanguin de branchement à partir d’un animal vertébré (donneur), (b) une étape de décellularisation du vaisseau sanguin, et (c) une étape d’adhésion de la partie à partir de laquelle la ramification a été excisée par un traitement de dénaturation de protéine et de fermeture du vaisseau. La présente invention concerne en outre une composition de greffe comprenant un matériau biocompatible qui comprend le matériau décellularisé pour une transplantation.
(JA) 移植片組成物に利用可能な、糸による縫合部を最小限に抑えた移植用脱細胞化材料を製造する方法を提供することを目的とする。 上記目的を達成するため、本発明は(a)脊椎動物(ドナー)から分枝を有する血管を採取する工程、(b)当該血管を脱細胞化する工程、及び(c)分枝を切除した部分をタンパク質変性処理により接着し閉管する工程を含む、移植用脱細胞化材料の製造方法を提供する。さらに、本発明は当該移植用脱細胞化材料を含む生体適合性材料からなる移植片組成物も提供する。
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Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)