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1. (WO2018220623) COMPOSITIONS AND METHODS FOR PROVIDING CELL REPLACEMENT THERAPY

Pub. No.:    WO/2018/220623    International Application No.:    PCT/IL2018/050580
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Mon May 28 01:59:59 CEST 2018
IPC: A61K 35/39
A61K 35/12
C12N 15/63
C12N 5/071
C12N 15/861
A61P 3/10
A61P 5/48
A61P 5/50
Applicants: ORGENESIS LTD.
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventors: FERBER, Sarah
Title: COMPOSITIONS AND METHODS FOR PROVIDING CELL REPLACEMENT THERAPY
Abstract:
Disclosed is a three-dimensional (3D) cell cluster comprising transdifferentiated adult mammalian non-pancreatic beta cells having a mature pancreatic beta cell phenotype and function, wherein the transdifferentiated cells have an enhanced mature pancreatic beta cell phenotype compared to similarly transdifferentiated cells cultured as a 2D monolayer.