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|1. (WO2018220623) COMPOSITIONS AND METHODS FOR PROVIDING CELL REPLACEMENT THERAPY|
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
|Title:||COMPOSITIONS AND METHODS FOR PROVIDING CELL REPLACEMENT THERAPY|
Disclosed is a three-dimensional (3D) cell cluster comprising transdifferentiated adult mammalian non-pancreatic beta cells having a mature pancreatic beta cell phenotype and function, wherein the transdifferentiated cells have an enhanced mature pancreatic beta cell phenotype compared to similarly transdifferentiated cells cultured as a 2D monolayer.