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1. (WO2018220622) COMPOSITIONS AND METHODS FOR PROVIDING CELL REPLACEMENT THERAPY

Pub. No.:    WO/2018/220622    International Application No.:    PCT/IL2018/050579
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Mon May 28 01:59:59 CEST 2018
IPC: C12N 5/07
Applicants: ORGENESIS LTD.
TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD.
Inventors: FERBER, Sarah
Title: COMPOSITIONS AND METHODS FOR PROVIDING CELL REPLACEMENT THERAPY
Abstract:
Disclosed is a three-dimensional (3D) cell cluster comprising transdifferentiated adult mammalian non-pancreatic beta cells having a mature pancreatic beta cell phenotype and function and a scaffold, wherein said transdifferentiated cells have an enhanced mature pancreatic beta cell phenotype compared to a 3D cell cluster without a scaffold and to similarly transdifferentiated cells cultured as a two-dimensional (2D) monolayer.