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1. (WO2018220616) GENETIC SYSTEMS THAT DEFEND AGAINST FOREIGN DNA AND USES THEREOF
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Pub. No.: WO/2018/220616 International Application No.: PCT/IL2018/050559
Publication Date: 06.12.2018 International Filing Date: 23.05.2018
IPC:
C12N 15/31 (2006.01) ,C07K 14/195 (2006.01) ,A61K 38/16 (2006.01) ,A61K 39/02 (2006.01) ,A23L 5/00 (2016.01) ,G06F 19/00 (2018.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
11
DNA or RNA fragments; Modified forms thereof
31
Genes encoding microbial proteins, e.g. enterotoxins
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
02
Bacterial antigens
[IPC code unknown for A23L 5]
G PHYSICS
06
COMPUTING; CALCULATING; COUNTING
F
ELECTRIC DIGITAL DATA PROCESSING
19
Digital computing or data processing equipment or methods, specially adapted for specific applications
Applicants:
YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; at The Weizmann Institute of Science P.O. Box 95 7610002 Rehovot, IL
Inventors:
SOREK, Rotem; IL
OFIR, Gal; IL
AMITAI, Gil; IL
MELAMED, Sarah; IL
DORON, Shany; IL
LEAVITT, Azita; IL
Agent:
COHEN, Mark S.; IL
Priority Data:
62/512,21630.05.2017US
62/512,21930.05.2017US
62/586,91116.11.2017US
Title (EN) GENETIC SYSTEMS THAT DEFEND AGAINST FOREIGN DNA AND USES THEREOF
(FR) SYSTÈMES GÉNÉTIQUES DE DÉFENSE CONTRE L'ADN ÉTRANGER ET LEURS UTILISATIONS
Abstract:
(EN) Disclosed herein are microbial defense systems, which provide cells protection against phage infection and plasmid transformation. Methods of use of these defense systems for protecting cells from phage infection and plasmid transformation are also disclosed, wherein defense systems may be used individually or in combination. In addition, disclosed herein are methods of making cells that express these defense systems.
(FR) L'invention concerne des systèmes de défense microbienne, qui fournissent aux cellules une protection contre une infection phagique et une transformation plasmidique. L'invention concerne également des méthodes d'utilisation de ces systèmes de défense pour protéger des cellules contre une infection phagique et une transformation plasmidique, les systèmes de défense pouvant être utilisés individuellement ou en association. L'invention concerne en outre des méthodes de fabrication de cellules qui expriment ces systèmes de défense.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)