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1. (WO2018220603) THE PREPARATION OF CERAMIDE CONJUGATES AND DERIVATIVES OF SPHINGOLIPID ANALOGUES
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Pub. No.: WO/2018/220603 International Application No.: PCT/IB2018/053967
Publication Date: 06.12.2018 International Filing Date: 04.06.2018
IPC:
C07K 7/02 (2006.01) ,A61K 47/54 (2017.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
7
Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
02
Linear peptides containing at least one abnormal peptide link
[IPC code unknown for A61K 47/54]
Applicants:
BOVIN, Nicolai Vladimirovich [RU/RU]; RU
HENRY, Stephen Micheal [NZ/NZ]; NZ
TUZIKOV, Alexander Borisovich [RU/RU]; RU
Inventors:
BOVIN, Nicolai Vladimirovich; RU
HENRY, Stephen Micheal; NZ
TUZIKOV, Alexander Borisovich; RU
Agent:
PARKER, Stephen Robert; NZ
Priority Data:
201790210402.06.2017AU
201790210502.06.2017AU
Title (EN) THE PREPARATION OF CERAMIDE CONJUGATES AND DERIVATIVES OF SPHINGOLIPID ANALOGUES
(FR) PRÉPARATION DE CONJUGUÉS DE CÉRAMIDES ET DE DÉRIVÉS D'ANALOGUES DE SPHINGOLIPIDES
Abstract:
(EN) The preparation of water dispersible ceramide conjugates and derivatives of sphingolipid analogues is described. The conjugates and analogues are prepared by reacting a succinimidyl carbonate of a β-Ala derivative with the primary amine of a functionalised spacer. Despite their dispersibility in water, the ceramide conjugates and derivatives of sphingolipid analogues spontaneously incorporate into the plasma membranes of cells.
(FR) L'invention concerne la préparation de conjugués de céramides dispersibles dans l'eau et de dérivés d'analogues de sphingolipides. Les conjugués et les analogues sont préparés par réaction d'un carbonate de succinimidyle d'un dérivé de β-Ala avec l'amine primaire d'un espaceur fonctionnalisé. Malgré leur dispersibilité dans l'eau, les conjugués de céramides et les dérivés d'analogues de sphingolipides intègrent de manière spontanée les membranes plasmiques de cellules.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)