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1. (WO2018220533) METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND

Pub. No.:    WO/2018/220533    International Application No.:    PCT/IB2018/053822
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: C07D 417/12
Applicants: MILLENNIUM PHARMACEUTICALS, INC.
ミレニアム ファーマシューティカルズ, インコーポレイテッド
Inventors: HIRANO, Sayuri
平野 沙悠梨
TAKEDA, Yoshiyuki
武田 善行
NAKAMOTO, Koji
中本 幸治
IKEUCHI, Motoki
池内 元樹
KITAYAMA, Masato
北山 理乙
YAMADA, Masatoshi
山田 雅俊
KAWAKAMI, Jun-ichi
川上 淳一
Title: METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND
Abstract:
Provided is a method for producing an optically active pyrimidine amide derivative that can be produced on an industrial scale. Compound (I), (V) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, the obtained compound (III) or a salt thereof is reacted with compound (IV) or a salt thereof, and compound (V) or a salt thereof is obtained. (In the formulas, the symbols are as defined in the description.)