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|1. (WO2018220533) METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND|
|Applicants:||MILLENNIUM PHARMACEUTICALS, INC.
ミレニアム ファーマシューティカルズ， インコーポレイテッド
|Title:||METHOD FOR PRODUCING OPTICALLY ACTIVE COMPOUND|
Provided is a method for producing an optically active pyrimidine amide derivative that can be produced on an industrial scale. Compound (I), (V) or a salt thereof is subjected to an asymmetric reduction reaction, the obtained compound (II) or a salt thereof is subjected to a deprotection reaction, the obtained compound (III) or a salt thereof is reacted with compound (IV) or a salt thereof, and compound (V) or a salt thereof is obtained. (In the formulas, the symbols are as defined in the description.)