Search International and National Patent Collections

1. (WO2018220489) METHODS OF OBTAINING CELLS FROM HUMAN POSTPARTUM UMBILICAL CORD ARTERIAL TISSUE

Pub. No.:    WO/2018/220489    International Application No.:    PCT/IB2018/053717
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Fri May 25 01:59:59 CEST 2018
IPC: C12N 5/073
A61K 35/51
A61P 27/02
Applicants: JANSSEN BIOTECH, INC.
Inventors: HARRIS, Ian Ross
DEJNEKA, Nadine S.
Title: METHODS OF OBTAINING CELLS FROM HUMAN POSTPARTUM UMBILICAL CORD ARTERIAL TISSUE
Abstract:
The invention provides for methods of obtaining cells from mammalian, preferably human, postpartum umbilical cord arterial tissue and use of these cells to treat ocular degenerative conditions. In particular, methods of the invention result in the isolation of a homogenous population of human postpartum umbilical cord arterial tissue-derived cells. In certain embodiments, the cells: express CD13, CD90, NG2, and HLA-ABC; do not express one or more of CD31, CD34, CD45, CD117, FSP1, and E-cadherin. In other embodiments, the cells secrete one or more of thrombospondin-1, BDNF and sVEGFR1.