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1. (WO2018220467) ANTI-MUC18 HUMAN IMMUNOTOXIN AND APPLICATIONS THEREOF

Pub. No.:    WO/2018/220467    International Application No.:    PCT/IB2018/053536
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sun May 20 01:59:59 CEST 2018
IPC: A61K 39/395
C07K 16/00
A61P 35/00
Applicants: NEJATOLLAHI, Foroogh
Inventors: NEJATOLLAHI, Foroogh
MOHAMMADI, Mozafar
Title: ANTI-MUC18 HUMAN IMMUNOTOXIN AND APPLICATIONS THEREOF
Abstract:
Disclosed herein is an anti-MUC18 immunotoxin including an anti-MUC18 single-chain variable fragment (scFv) with a nucleotide sequence as set forth in SEQ ID No. 3, and a truncated Pseudomonas exotoxin A (PEA) with a nucleotide sequence as set forth in SEQ ID No. 5. The truncated PEA may be conjugated with the scFv through a connector.