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1. (WO2018220457) VITAMIN B1 IN HIGH DOSES FOR USE IN THE MEDICAL TREATMENT OF MOTOR SYMPTOMS OF SOME SPORADIC NEURODEGENERATIVE DISEASES, OF GENETIC ORIGIN, AND OF CLUSTER HEADACHE AND OF MIGRAINE HEADACHE

Pub. No.:    WO/2018/220457    International Application No.:    PCT/IB2018/053291
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat May 12 01:59:59 CEST 2018
IPC: A61K 31/51
A61P 25/16
A61P 25/14
A61P 25/06
Applicants: COSTANTINI, Antonio
COLANGELI, Marco
PALA, Maria Immacolata
FANCELLU, Roberto
Inventors: COSTANTINI, Antonio
Title: VITAMIN B1 IN HIGH DOSES FOR USE IN THE MEDICAL TREATMENT OF MOTOR SYMPTOMS OF SOME SPORADIC NEURODEGENERATIVE DISEASES, OF GENETIC ORIGIN, AND OF CLUSTER HEADACHE AND OF MIGRAINE HEADACHE
Abstract:
The present invention relates to the use of vitamin B1 and to pharmaceutical compositions including it, in the treatment of motor symptoms of some sporadic neurodegenerative diseases (that is not of genetic origin), of genetic origin and of the primary headaches (cluster headache and migraine headache). In particular the present invention relates to vitamin B1 for use in the treatment of motor symptoms of one of the following pathologies: Essential Tremor (also called induced tremor), Dystonia 1 (DYT1), Huntington's Chorea, Sporadic spinocerebellar ataxia, Atypical Parkinsonisms (multisystemic atrophy of Parkinson type and Cerebellar type, progressive supranuclear paralysis, Cortico-basal degeneration); and headache episodes of Cluster headache and Migraine headache.