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1. (WO2018220398) DIRECT TISSUE ANALYSIS

Pub. No.:    WO/2018/220398    International Application No.:    PCT/GB2018/051508
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: H01J 49/04
H01J 49/16
Applicants: MICROMASS UK LIMITED
Inventors: HART, Philippa J.
CLAUDE, Emmanuelle
PRINGLE, Steven Derek
KARANCSI, Tamás
JONES, Emrys
TOWERS, Mark
Title: DIRECT TISSUE ANALYSIS
Abstract:
A method of analysing peptides and/or proteins directly from a surface of a tissue sample is disclosed. The method comprises directing a spray of solvent droplets (13) from a sprayer device (10) onto a surface of the tissue sample (20). The solvent droplets then generate peptide and/or protein ions from the surface of the tissue sample by a process of desorption. The generated ions can then be collected using a sampling orifice (30) and analysed by an ion analyser.