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1. (WO2018220386) NANONETS AND SPHERICAL PARTICLES
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Pub. No.: WO/2018/220386 International Application No.: PCT/GB2018/051495
Publication Date: 06.12.2018 International Filing Date: 31.05.2018
IPC:
C07K 14/315 (2006.01) ,A61K 39/00 (2006.01) ,A61K 39/385 (2006.01) ,C07K 19/00 (2006.01) ,C12N 7/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195
from bacteria
315
from Streptococcus (G), e.g. Enterococci
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
385
Haptens or antigens, bound to carriers
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
19
Hybrid peptides
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
04
Inactivation or attenuation; Producing viral sub-units
Applicants:
THE JAMES HUTTON INSTITUTE [GB/GB]; Invergowrie Dundee Tayside DD2 5DA, GB
Inventors:
LOVE, Andrew, John; GB
TALIANSKI, Mikhail, Emmanuilovich; GB
MCGEACHY, Kara; GB
Agent:
MURGITROYD & COMPANY; Scotland House 165-169 Scotland Street Glasgow G5 8PL, GB
Priority Data:
1708675.231.05.2017GB
Title (EN) NANONETS AND SPHERICAL PARTICLES
(FR) NANORÉSEAUX ET PARTICULES SPHÉRIQUES
Abstract:
(EN) The present invention relates to macromolecular complexes comprising micron-scale networks which include binding motifs thereon which allow the covalent bonding of the micron-scale networks to particles which provide nanoscale display surfaces. In particular the present invention relates to micron-scale networks of TMV coat proteins comprising a peptide tag (e.g. SpyTag) and particles providing a nanoscale display surface comprising GFP and a corresponding binding protein (e.g. SpyCatcher) wherein the peptide tag and binding protein pair are capable of spontaneously forming a covalent bond.
(FR) La présente invention concerne des complexes macromoléculaires renfermant des réseaux à l'échelle micrométrique qui comportent des motifs de liaison permettant de lier de manière covalente des réseaux à l'échelle micrométrique à des particules qui fournissent des surfaces d'affichage à l'échelle nanométrique. La présente invention concerne particulièrement des réseaux à l'échelle micrométrique de protéines de revêtement TMV comprenant une étiquette peptidique (par exemple, SpyTag) et des particules fournissant une surface d'affichage à l'échelle nanométrique comprenant une GFP et une protéine de liaison correspondante (par exemple, SpyCatcher), l'étiquette peptidique et la paire de protéines de liaison étant capables de former spontanément une liaison covalente.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)