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1. (WO2018220355) SULFONAMIDE-SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS DUB INHIBITORS

Pub. No.:    WO/2018/220355    International Application No.:    PCT/GB2018/051454
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Thu May 31 01:59:59 CEST 2018
IPC: A61K 31/40
A61K 31/496
A61K 31/506
C07D 403/12
C07D 401/14
A61K 31/4025
A61K 31/4155
A61K 31/4439
A61K 31/454
A61K 31/5365
C07D 401/12
C07D 403/14
C07D 487/04
C07D 207/14
C07D 498/02
A61P 31/00
A61P 25/00
A61P 3/00
A61P 29/00
A61P 35/00
Applicants: MISSION THERAPEUTICS LIMITED
Inventors: STOCKLEY, Martin Lee
KEMP, Mark Ian
MADIN, Andrew
WOODROW, Michael David
Title: SULFONAMIDE-SUBSTITUTED CYANOPYRROLIDINES WITH ACTIVITY AS DUB INHIBITORS
Abstract:
The present invention relates to a class of sulfonamide-substituted cyanopyrrolidines of Formula (Ia) and (Ib) with activity as inhibitors of deubiquitilating enzymes, in particular, ubiquitin C-terminal hydrolase L1 (UCHL1) and ubiquitin C-terminal hydrolase 30 or ubiquitin specific peptidase 30 (USP30), having utility in a variety of therapeutic areas including cancer and conditions involving mitochondrial dysfunction: (Formulae (Ia), (Ib)).