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1. (WO2018220249) IN VITRO METHOD FOR IDENTIFYING SEVERITY LEVELS IN PATIENTS WITH BRONCHIAL ASTHMA

Pub. No.:    WO/2018/220249    International Application No.:    PCT/ES2018/070390
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Wed May 30 01:59:59 CEST 2018
IPC: C12Q 1/6883
Applicants: FUNDACIÓN INSTITUTO DE INVESTIGACIÓN SANITARIA FUNDACIÓN JIMÉNEZ DÍAZ
CENTRO DE INVESTIGACIÓN BIOMÉDICA EN RED (CIBER)
FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO LA PAZ
FUNDACIÓN CONCHITA RÁBAGO DE JIMÉNEZ DÍAZ
Inventors: DEL POZO ABEJÓN, Victoria
SASTRE DOMINGUEZ, Joaquín
RODRIGO-MUÑOZ, José Manuel
SASTRE TURRIÓN, Beatriz
QUIRCE GANCEDO, Santiago
CAÑAS MAÑAS, José Antonio
Title: IN VITRO METHOD FOR IDENTIFYING SEVERITY LEVELS IN PATIENTS WITH BRONCHIAL ASTHMA
Abstract:
The present invention shows that miR-185-5p exhibits higher levels of relative expression (2-ΔCt, where ΔCt= Ct miRNA of interest (miR-185-5p) -Ct endogenous miRNA) in asthma patients than in healthy individuals. Moreover, the levels of expression of miR-185-5p differ not only between healthy individuals and asthma patients, but also between healthy individuals and each of the subgroups of asthma patients (intermittent, persistent mild, moderate and severe). The results further show that the last two severity levels, the persistent moderate and severe levels, exhibit a gradation or progressive increase in expression in comparison with intermittent and persistent mild levels.