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1. (WO2018220234) ADAMTS BINDING IMMUNOGLOBULINS

Pub. No.:    WO/2018/220234    International Application No.:    PCT/EP2018/064665
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Tue Jun 05 01:59:59 CEST 2018
IPC: C07K 16/40
A61K 39/395
A61P 19/02
Applicants: MERCK PATENT GMBH
ABLYNX N.V.
Inventors: BUYSE, Marie-Ange
HERMANS, Guy
LINDEMANN, Sven
GUEHRING, Hans
GUENTHER, Ralf
KELLNER, Roland
Title: ADAMTS BINDING IMMUNOGLOBULINS
Abstract:
The present invention relates to immunoglobulins that bind ADAMTS5 and more in particular to polypeptides, that comprise or essentially consist of one or more such immunoglobulins. The invention also relates to constructs comprising such immunoglobulins, such as immunoglobulin single variable domains (ISVDs) or polypeptides as well as nucleic acids encoding such immunoglobulins or polypeptides; to methods for preparing such immunoglobulins, polypeptides and constructs; to host cells expressing or capable of expressing such immunoglobulins or polypeptides; to compositions, and in particular to pharmaceutical compositions, that comprise such immunoglobulins, polypeptides, constructs, nucleic acids and/or host cells; and to uses of immunoglobulins, polypeptides, constructs, nucleic acids, host cells and/or compositions, in particular for prophylactic and/or therapeutic purposes, such as the prophylactic and/or therapeutic purposes mentioned herein. Other aspects, embodiments, advantages and applications of the invention will become clear from the further description herein.