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1. (WO2018220231) METHOD FOR MONITORING AND/OR PREDICTING THE EFFICACY OF TREATMENT IN A MULTIPLE SCLEROSIS PATIENT

Pub. No.:    WO/2018/220231    International Application No.:    PCT/EP2018/064645
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Tue Jun 05 01:59:59 CEST 2018
IPC: G01N 33/68
Applicants: FUNDACIÓN PARA LA INVESTIGACIÓN BIOMÉDICA DEL HOSPITAL UNIVERSITARIO RAMÓN Y CAJAL
Inventors: VILLAR GUIMERANS, Luisa María
ÁLVAREZ CERMEÑO, José Carlos
COSTA-FROSSARD FRANCA, Lucienne
SAINZ DE LA MAZA CANTERO, Susana
ROLDÁN SANTIAGO, Ernesto
VILLARRUBIA MIGALLÓN, Noelia
MEDINA HERAS, Silvia
Title: METHOD FOR MONITORING AND/OR PREDICTING THE EFFICACY OF TREATMENT IN A MULTIPLE SCLEROSIS PATIENT
Abstract:
The present invention provides a new method for determining whether a dimethyl fumarate 10 treatment is effective for a particular Multiple Sclerosis (MS) patient.A pro-tolerogenic shift in the blood leukocyte profile associates with an optimal response to DMF in(relapse remitting MS)RRMS patients. This method and the kit to perform it, allowsfor the identification ofgood responders to DMF treatment once drug administration has been initiated.