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1. (WO2018220225) AGGRECAN BINDING IMMUNOGLOBULINS

Pub. No.:    WO/2018/220225    International Application No.:    PCT/EP2018/064608
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Tue Jun 05 01:59:59 CEST 2018
IPC: C07K 16/18
C07K 16/40
C07K 16/46
A61K 39/395
A61P 19/02
Applicants: ABLYNX NV
MERCK PATENT GMBH
Inventors: STEFFENSEN, Soren
BESTE, Gerald
HERMANS, Guy
GÜHRING, Hans
LADEL, Christoph
TOLEIKIS, Lars
Title: AGGRECAN BINDING IMMUNOGLOBULINS
Abstract:
The present invention relates to immunoglobulins that specifically bind Aggrecan and more in particular to polypeptides, nucleic acids encoding such polypeptides; to methods for preparing such polypeptides; to compositions and in particular to pharmaceutical compositions that comprise such polypeptides, for prophylactic, therapeutic or diagnostic purposes. In particular, the immunoglobulins of the present invention inhibit the activity of Aggrecan.