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1. (WO2018220224) LIPID-RELATED ANTIGENS AND ANTIBODIES DIRECTED AGAINST THEM

Pub. No.:    WO/2018/220224    International Application No.:    PCT/EP2018/064604
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Tue Jun 05 01:59:59 CEST 2018
IPC: C07K 16/18
C07K 16/44
A61K 31/519
A61K 38/00
A61K 38/17
A61K 39/002
Applicants: MEDIRISTA BIOTECHNOLOGIES AB
Inventors: FROSTEGÅRD, Johan
Title: LIPID-RELATED ANTIGENS AND ANTIBODIES DIRECTED AGAINST THEM
Abstract:
It is found herein that actively or passively raising the antibody levels against lipid-related antigens such as malondialdehyde and phosphorylcholine can be used in combination therapy with an antineoplastic agent such as methotrexate in mammals in order to treat or to prevent the development of rheumatic diseases, cancers, SLE and CVD. The invention also relates to compositions comprising lipid-related antigens or antibodies against malondialdehyde and/or antibodies against phosphorylcholine and one or more antineoplastic agent such as methotrexate and to the use of such compositions.