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1. (WO2018220149) COMPOUNDS

Pub. No.:    WO/2018/220149    International Application No.:    PCT/EP2018/064399
Publication Date: Fri Dec 07 00:59:59 CET 2018 International Filing Date: Sat Jun 02 01:59:59 CEST 2018
IPC: C07D 417/12
C07D 417/14
A61P 35/00
A61K 31/427
Applicants: F. HOFFMANN-LA ROCHE AG
HOFFMANN-LA ROCHE INC.
C4 THERAPEUTICS, INC.
Inventors: JAESCHKE, Georg
RICCI, Antonio
RUEHER, Daniel
STEINER, Sandra
DUPLESSIS, Martin
NAGEL, Yvonne Alice
KUHN, Bernd
Title: COMPOUNDS
Abstract:
The present invention provides compounds which are selective allosteric inhibitors of TMLR, TMLRCS, LR, LRCS containing EGFR mutants, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances.