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1. (WO2018220113) METHOD FOR PRODUCING ALBICANOL AND/OR DRIMENOL
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Pub. No.: WO/2018/220113 International Application No.: PCT/EP2018/064344
Publication Date: 06.12.2018 International Filing Date: 31.05.2018
IPC:
C12P 7/02 (2006.01) ,C12N 9/30 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
7
Preparation of oxygen-containing organic compounds
02
containing a hydroxy group
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
14
Hydrolases (3.)
24
acting on glycosyl compounds (3.2)
26
acting on alpha-1, 4-glucosidic bonds, e.g. hyaluronidase, invertase, amylase
28
Alpha-amylase from microbial source, e.g. bacterial amylase
30
Fungal source
Applicants:
FIRMENICH SA [CH/CH]; 1, route des Jeunes P.O. Box 239 1211 Geneva 8, CH
Inventors:
SCHALK, Michel; CH
ANZIANI, Pauline; CH
GOERNER, Christian; CH
SOLIS ESCALANTE, Daniel; CH
Agent:
BAUMGARTNER HARRIS, Pauline; CH
Priority Data:
17174399.002.06.2017EP
Title (EN) METHOD FOR PRODUCING ALBICANOL AND/OR DRIMENOL
(FR) MÉTHODE DE PRODUCTION D'ALBICANOL ET/OU DE DRIMÉNOL
Abstract:
(EN) The present application relates to a method of producing a drimane sesquiterpene such as albicanol, drimenol and/or derivatives thereof by contacting at least one polypeptide with farnesyl diphosphate (FPP) with a polypeptide comprising a Haloacid dehalogenase (HAD)-like hydrolase domain and having bifunctional terpene synthase activity. The method may be 5 performed in vitro or in vivo. Also provided are amino acid sequences of polypeptides useful in the methods and nucleic acids encoding the polypeptides described. The method further provides host cells or organisms genetically modified to express the polypeptides and useful to produce a drimane sesquiterpene such as albicanol, drimenol and/or derivatives thereof.
(FR) La présente invention concerne une méthode de production d'un sesquiterpène drimane tel que l'albicanol, le driménol et/ou des dérivés de ceux-ci par mise en contact d'au moins un polypeptide avec du farnésyl diphosphate (FPP) avec un polypeptide comprenant un domaine hydrolase de type haloacide déshalogénase (HAD) et ayant une activité de terpène synthase bifonctionnelle. La méthode peut être mise en œuvre in vitro ou in vivo. L'invention concerne également des séquences d'acides aminés de polypeptides utiles dans les méthodes et des acides nucléiques codant pour les polypeptides décrits. La méthode concerne, en outre, des cellules hôtes ou des organismes génétiquement modifiés pour exprimer les polypeptides et utiles pour produire un sesquiterpène drimane tel que l'albicanol, le driménol et/ou des dérivés de ceux-ci.
Designated States: AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Office (AM, AZ, BY, KG, KZ, RU, TJ, TM)
European Patent Office (EPO) (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)